Hexa-D-arginine TFA ( Furin Inhibitor II TFA )

产品货号. M29859 CAS No. 958204-56-3

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货

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生物学信息

产品名称

Hexa-D-arginine TFA
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively).
产品描述

Hexa-D-arginine TFA (Furin Inhibitor II TFA) is an inhibitor of furin (Ki values are 0.106, 0.58 and 13.2 μM for furin, PACE4 and PC1 respectively). (In Vitro):Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.(In Vivo):Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.
体外实验

Hexa-D-arginine effectively blocks Pseudomonas aeruginosa exotoxin A (PEA)-induced cell lysis and is itself noncytotoxic.
体内实验

Administration of Hexa-D-arginine (0.1, 1, or 10 nM) to Pseudomonas aeruginosa exotoxin A (PEA)-treated mice (6-week-old FVB and 129/Sv mice) significantly improves their survival rate and also decreases circulating levels of TNF-α.
同义词

Furin Inhibitor II TFA
通路

GPCR/G Protein
靶点

Antibacterial
受体

Ki: 106 nM (Furin), 580 nM (PACE4) and 13.2 μM (PC1)
研究领域

——
适应症

——

化学信息

CAS Number

958204-56-3
分子量

1068.17
分子式

C38H76F3N25O8
纯度

>98% (HPLC)
溶解度

——
SMILES

——
化学全称

Sequence:Arg-Arg-Arg-Arg-Arg-Arg-NH2

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

Sarac MS, et al. The furin inhibitor hexa-D-arginine blocks the activation of Pseudomonas aeruginosa exotoxin A in vivo. Infect Immun. 2002 Dec;70(12):7136-9.

计算器

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摩尔计算器

分子量计算器

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